MutL: conducting the cell's response to mismatched and misaligned DNA.

@article{Polosina2010MutLCT,
  title={MutL: conducting the cell's response to mismatched and misaligned DNA.},
  author={Yaroslava Y. Polosina and Claire G. Cupples},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2010},
  volume={32 1},
  pages={51-9}
}
Base pair mismatches in DNA arise from errors in DNA replication, recombination, and biochemical modification of bases. Mismatches are inherently transient. They are resolved passively by DNA replication, or actively by enzymatic removal and resynthesis of one of the bases. The first step in removal is recognition of strand discontinuity by one of the MutS proteins. Mismatches arising from errors in DNA replication are repaired in favor of the base on the template strand, but other mismatches… CONTINUE READING

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