Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

  title={Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1},
  author={Sven-Eric Jordt and Diana M. Bautista and Huai-hu Chuang and David D. McKemy and Peter M. Zygmunt and Edward D. H{\"o}gest{\"a}tt and Ian D. Meng and David Julius},
Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory nerve endings, thereby producing pain, inflammation and robust hypersensitivity to thermal and mechanical stimuli. Despite their widespread use in both the kitchen and the laboratory, the molecular mechanism through which isothiocyanates mediate their effects remains unknown. Here we show that mustard oil depolarizes a… 

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