Mustard Gas: Imminent Danger or Eminent Threat?

@article{Geraci2008MustardGI,
  title={Mustard Gas: Imminent Danger or Eminent Threat?},
  author={Matthew J. Geraci},
  journal={Annals of Pharmacotherapy},
  year={2008},
  volume={42},
  pages={237 - 246}
}
  • M. Geraci
  • Published 1 February 2008
  • Medicine
  • Annals of Pharmacotherapy
Objective: To increase awareness of the widespread environmental prevalence of the chemical warfare agent mustard gas, examine the acute and chronic toxic effects to exposed humans, and discuss medical treatment guidelines for mustard gas exposures. Data Sources: Literature retrieval of medical case reports and clinical studies was accomplished using PubMed and the Cochrane Database (1919–March 2007). Search terms included mustard, mustard gas, sulfur mustard, chemical warfare, blister agents… 
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TLDR
Mustard gas keratopathy (MGK) is a devastating late complication of SM intoxication that proceeds from limbal stem cell deficiency (LSCD) and leading to a broad spectrum of ocular manifestations in terms of severity, timing and form.
Therapeutic measures for sulfur mustard-induced ocular injury.
TLDR
This review focuses on treatment experience carried out in humans and studied in animal models, for both SM-induced ocular acute injury and late pathology, and investigates the potential of additional pharmacological and biological treatments or advanced cellular and molecular biology methods to serve as novel therapeutic measures and techniques for this complicated ocular injury.
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References

SHOWING 1-10 OF 157 REFERENCES
Mustard: a potential agent of chemical warfare and terrorism
TLDR
The dose‐dependent effects of acute sulphur mustard exposure on the skin, eyes, and respiratory system are described, as well as the possible extents of injuries, the mechanisms of action and the long‐term complications.
Exposure to liquid sulfur mustard.
TLDR
The first case of an exposure to mustard at a storage facility, as well as the first documented incident occurring in the United States, are reported.
Treating exposure to chemical warfare agents: implications for health care providers and community emergency planning.
Current treatment protocols for exposure to nerve and vesicant agents found in the U.S. stockpile of unitary chemical weapons are summarized, and the toxicities of available antidotes are evaluated.
Mustard Gas: Clinical, Toxicological, and Mutagenic Aspects Based on Modern Experience
TLDR
The clinical effects, and toxicological and mutagenic properties of the agent are outlined, and the risk of developing cancer may be increased, as observed in people who were involved with the production of mustard gas and in animals exposed to the gas.
Toxicology of mustard gas.
  • U. Wormser
  • Chemistry, Medicine
    Trends in pharmacological sciences
  • 1991
TLDR
The structure--activity studies that are available, and the limited pharmacological measures that can be taken to protect against mustard gas attack are discussed, and new percutaneous preparations are developed which offer better protection than is possible with simple adsorbant powders.
Toxicology and pharmacology of the chemical warfare agent sulfur mustard.
TLDR
The need to assess the affect of a suspected teratogen on maternal toxicity in laboratory animals is emphasized, as evidence of an association between lung cancer and mustard gas encountered on the battlefields of World War I is at best suggestive if not problematical.
Ocular injury by mustard gas.
TLDR
In light of the ever-present threat of mustard chemical warfare against military and civilians, physicians worldwide should be aware of its grave effects and know how to care for its victims.
Medical Aspects of Chemical and Biological Warfare
Abstract : This volume was prepared for military medical educational use. The focus of the information is to foster discussion that may form the basis of doctrine and policy. Until this decade, our
Sulfur mustard: its continuing threat as a chemical warfare agent, the cutaneous lesions induced, progress in understanding its mechanism of action, its long-term health effects, and new developments for protection and therapy.
TLDR
The recent development of a topical skin protectant for SM and for other chemical warfare agents may have broad applications within dermatology, and new findings related to the effects of SM on the basement membrane zone will increase the understanding of the pathophysiology of the lesions caused by SM.
Toxicodynamics of sulfur mustard.
  • S. Somani, S. R. Babu
  • Chemistry, Medicine
    International journal of clinical pharmacology, therapy, and toxicology
  • 1989
TLDR
An integrated panorama of mustard gas--its chemical nature, mode of action, methods available for its analysis in biological fluids and target organs, absorption, distribution, metabolism and excretion and its toxicity to various organs is presented.
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