Mussel-inspired polydopamine: a biocompatible and ultrastable coating for nanoparticles in vivo.

  title={Mussel-inspired polydopamine: a biocompatible and ultrastable coating for nanoparticles in vivo.},
  author={Xiangshen Liu and Jie-ming Cao and Huan Li and Jianyu Li and Qiao Jin and Ke‐feng Ren and Jian Ji},
  journal={ACS nano},
  volume={7 10},
Bioinspired polydopamine (PDA) has served as a universal coating to nanoparticles (NPs) for various biomedical applications. However, one remaining critical question is whether the PDA shell on NPs is stable in vivo. In this study, we modified gold nanoparticles (GNPs) with finely controlled PDA nanolayers to form uniform core/shell nanostructures (GNP@PDA). In vitro study showed that the PDA-coated GNPs had low cytotoxicity and could smoothly translocate to cancer cells. Transmission electron… 

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