Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1.

  title={Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1.},
  author={Josephine C. Adams and Brian Seed and Jack W Lawler},
  journal={The EMBO journal},
  volume={17 17},
We have used an expression cloning strategy based on a cell-attachment assay screen to seek identification of molecules required in cellular responses to thrombospondin-1, a regulated macromolecular component of extracellular matrix. We report the identification and functional characterization of a novel, widely expressed, intracellular protein, named muskelin, which contains dispersed motifs with homology to the tandem repeats first identified in the Drosophila kelch ORF1 protein. In adherent… CONTINUE READING


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