Mushroom body memoir: from maps to models

  title={Mushroom body memoir: from maps to models},
  author={Martin Heisenberg},
  journal={Nature Reviews Neuroscience},
  • M. Heisenberg
  • Published 1 April 2003
  • Biology
  • Nature Reviews Neuroscience
Genetic intervention in the fly Drosophila melanogaster has provided strong evidence that the mushroom bodies of the insect brain act as the seat of a memory trace for odours. This localization gives the mushroom bodies a place in a network model of olfactory memory that is based on the functional anatomy of the olfactory system. In the model, complex odour mixtures are assumed to be represented by activated sets of intrinsic mushroom body neurons. Conditioning renders an extrinsic mushroom… 

Using an Insect Mushroom Body Circuit to Encode Route Memory in Complex Natural Environments

It is demonstrated that abstracting the key computational principles of this circuit, which include one-shot learning of sparse codes, enables the theoretical storage capacity of the ant mushroom body to be estimated at hundreds of independent images.

Identification of mushroom body miniature, a zinc-finger protein implicated in brain development of Drosophila.

With a survey of genomic rescue constructs, this work has pinpointed mbm(1) to a single transcription unit and identified a single nucleotide exchange in the 5' untranslated region of the corresponding transcript resulting in a reduced expression of the protein.

Mushroom body miscellanea: transgenic Drosophila strains expressing anatomical and physiological sensor proteins in Kenyon cells

A collection of transgenic fruit flies that express transgenes under direct control of the Kenyon-cell specific promoter, mb247, facilitates combinations with binary transcription systems and might advance the physiological analysis of mushroom body function.

Drosophila Larvae Establish Appetitive Olfactory Memories via Mushroom Body Neurons of Embryonic Origin

10 subdomains of the larval mushroom body that may be implicated in mediating specific interactions between the olfactory pathway, modulatory neurons, and neuronal output are defined and anatomically disentangled at the single-cell level.

Olfactory memory formation in Drosophila: from molecular to systems neuroscience.

The Olfactory nervous system of insects and mammals exhibits many similarities, which suggests that the mechanisms for olfactory learning may be shared, and the genes identified to participate in Drosophila olfaction learning have conserved roles in mammalian organisms.

Structural Brain Mutants: Mushroom Body Defect (Mud): A Case Study

The history of mushroom body defect (mud) is traced, from the original anatomical description of the mutation to most recent insights of the function of the protein as a regulator of neuronal progenitor cell division.

The connectome of the adult Drosophila mushroom body: implications for function

This work identifies new components of the MB circuit in Drosophila, including extensive visual input and MB output neurons (MBONs) with direct connections to descending neurons, and provides insights into the circuitry used to integrate MB outputs, connectivity between the MB and the central complex and inputs to DANs, including feedback from MBONs.

Structured sampling of olfactory input by the fly mushroom body




Behavioral functions of the insect mushroom bodies

  • T. Zars
  • Biology
    Current Opinion in Neurobiology
  • 2000

The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen.

The data suggest that the mushroom body may not by itself be a "center" for learning and memory, but that it can equally be considered as a preprocessor of olfactory signals en route to "higher" protocerebral regions.

The Role of Drosophila Mushroom Body Signaling in Olfactory Memory

Inactivation of mushroom body signaling through α/β neurons during different phases of memory processing revealed a requirement for mushrooms body signaling during memory retrieval, but not during acquisition or consolidation.

Evolution, discovery, and interpretations of arthropod mushroom bodies.

An overview of the history of research on the mushroom bodies, as well as comparative and evolutionary considerations, provides a conceptual framework for discussing the roles of these neuropils.

Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies.

The results demonstrate that MBs mediate associative odor learning in flies, and that adult flies developing without MBs are unable to perform in a classical conditioning paradigm that tests associative learning of odor cues and electric shock.

Development of the Drosophila mushroom bodies: sequential generation of three distinct types of neurons from a neuroblast.

The cellular organization of mushroom bodies and the development of different MB neurons at the single cell level is illustrated to allow for future studies on the molecular mechanisms of mushroom body development.

What do the mushroom bodies do for the insect brain? an introduction.

In humans and other primates, lesions and noninvasive imaging techniques have provided fascinating insights into the underlying functional topology of the brain, but these approaches reveal structure–function relationships that are difficult to interpret in terms of network-based brain models.

Localization of Long-Term Memory Within the Drosophila Mushroom Body

It is shown that the alpha-lobes-absent (ala) mutant lacks either the two vertical lobes of the mushroom body or two of the three median lobes which contain branches of vertical lobe neurons, which allows analysis of mushroom body function.

Drosophila mushroom body mutants are deficient in olfactory learning.

Two Drosophila mutants are described in which the connections between the input to and the output from the mushroom bodies is largely interrupted, and the defect seems not to impair learning of color discrimination tasks or operant learning involving visual cues.