Musculosketal Symptoms and Non‐REM Sleep Disturbance in Patients with “Fibrositis Syndrome” and Healthy Subjects

  title={Musculosketal Symptoms and Non‐REM Sleep Disturbance in Patients with “Fibrositis Syndrome” and Healthy Subjects},
  author={Harvey Moldofsky and P Scarisbrick and Robert England and H. Smythe},
  journal={Psychosomatic Medicine},
&NA; In sleep studies of (a) patients with the “fibrositis syndrome” and (b) healthy subjects undergoing stage 4 sleep deprivation, we observed in both groups the anomalous presence of alpha‐rhythms in the non‐rapid‐eye‐movement (NREM) sleep EEG. This phenomenon has been termed alpha‐delta sleep. In the healthy subjects stage 4 deprivation was accompanied by the temporary appearance of muscoloskeletal and mood symptoms comparable to the symptoms seen chronically in the patients. It is suggested… 
Sleep in fibromyalgia patients: subjective and objective findings.
  • S. Harding
  • Medicine, Psychology
    The American journal of the medical sciences
  • 1998
Fibromyalgia, sleep disorder and chronic fatigue syndrome.
  • H. Moldofsky
  • Psychology, Medicine
    Ciba Foundation symposium
  • 1993
The chronic fatigue syndrome and fibromyalgia have similar disordered sleep physiology, namely an alpha rhythm disturbance in the electroencephalogram within non-rapid eye movement (NREM) sleep that accompanies increased nocturnal vigilance and light, unrefreshing sleep.
Fibromyalgia and sleep.
Sleep Disorders in Fibromyalgia Syndrome
Polysomnography in fibromyalgia patients reveals increased EEG alpha activity during non REM sleep, increased number of arousal and a more frequent occurrence of cyclic alternating pattern which supports the hypothesis of a conceptual common mechanism called central sensation.
Paradoxical NREMS distribution in "pure" chronic fatigue patients a comparison with sleep apnea-hypopnea patients and healthy control subjects
A retrospective comparison of the NREMS distribution was performed between 28 “pure” Chronic Fatigue Syndrome patients (without primary sleep or psychiatric disorders), 27 Apneic-Hypopneic patients and 27 Healthy Controls, and showed CFS patients to have a higher stage 4/stage 2 or stage4/light sleep ratios.
Sleep-stage dynamics in patients with chronic fatigue syndrome with or without fibromyalgia.
The results suggest that CFS and FM may be different illnesses associated with different problems of sleep regulation, and shorter durations of S2 sleep are specific to patients with CFS+FM, not to CFS alone.
Deciphering the Role of Sleep in Fibromyalgia Syndrome
Clinical trials of pharmacological and non-pharmacological therapies have shown that improving sleep quality can reduce pain and fatigue, further supporting the hypothesis that sleep dysfunction is a pathogenic stimulus of FMS.
Chronic Fatigue Syndrome and Fibromyalgia
Characteristics of Disturbed Sleep in Patients With Fibromyalgia Compared With Insomnia or With Pain-Free Volunteers
Increased frequency of wake and sleep bouts and decreased wake bout duration, together with decreased LPS and increased SWS, suggests that sleep in FM is characterized by an inability to maintain continuous sleep but a greater sleep drive compared with PI.