Musculoskeletal manifestations of sickle cell disease.

  title={Musculoskeletal manifestations of sickle cell disease.},
  author={Vivian C Ejindu and Andrew L Hine and Mohammad Mashayekhi and Philip J. Shorvon and Rakesh Misra},
  journal={Radiographics : a review publication of the Radiological Society of North America, Inc},
  volume={27 4},
Sickle cell disease results from the presence of abnormal beta globin chains within hemoglobin and may be manifested in anemia, vaso-occlusion, and superimposed infection. The gene that causes sickle cell disease is particularly prevalent in populations of African origin; approximately 8% of African Americans and 40% of the members of some African tribes carry the gene for hemoglobin S. Over time, the disease produces various musculoskeletal abnormalities as a result of chronic anemia; these… CONTINUE READING