Musculoskeletal integration at the wrist underlies the modular development of limb tendons.

@article{Huang2015MusculoskeletalIA,
  title={Musculoskeletal integration at the wrist underlies the modular development of limb tendons.},
  author={Alice H Huang and Timothy J. Riordan and Brian A Pryce and Jennifer L Weibel and Spencer Watson and Fanxin Long and Veronique Lefebvre and Brian D Harfe and Hannes Stadler and Haruhiko Akiyama and Sara F. Tufa and Douglas R. Keene and Ronen Schweitzer},
  journal={Development},
  year={2015},
  volume={142 14},
  pages={2431-41}
}
The long tendons of the limb extend from muscles that reside in the zeugopod (arm/leg) to their skeletal insertions in the autopod (paw). How these connections are established along the length of the limb remains unknown. Here, we show that mouse limb tendons are formed in modular units that combine to form a functional contiguous structure; in muscle-less limbs, tendons develop in the autopod but do not extend into the zeugopod, and in the absence of limb cartilage the zeugopod segments of… CONTINUE READING
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Experimental analysis of the role of ECM in the patterning of the distal tendons of the developing limb bud

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