Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial.

@article{Borst2014MusculoskeletalAP,
  title={Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial.},
  author={S. Borst and J. Yarrow and C. Conover and U. Nseyo and J. Meuleman and J. A. Lipinska and R. Braith and D. T. Beck and Jeffrey S. Martin and Matthew Morrow and S. Roessner and L. Beggs and S. McCoy and Darryl F. Cannady and J. Shuster},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={306 4},
  pages={
          E433-42
        }
}
Testosterone acts directly at androgen receptors and also exerts potent actions following 5α-reduction to dihydrotestosterone (DHT). Finasteride (type II 5α-reductase inhibitor) lowers DHT and is used to treat benign prostatic hyperplasia. However, it is unknown whether elevated DHT mediates either beneficial musculoskeletal effects or prostate enlargement resulting from higher-than-replacement doses of testosterone. Our purpose was to determine whether administration of testosterone plus… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to determine whether a higher-than-replacement dose of testosterone and finasteride can be combined to safely increase muscle strength in older men… Expand
ConditionsBenign Prostate Hypertrophy, Male Hypogonadism, Muscle Atrophy, (+1 more)
InterventionDrug, Other
Cognitive effects of testosterone and finasteride administration in older hypogonadal men
Injection of testosterone may be safer and more effective than transdermal administration for combating loss of muscle and bone in older men.
  • S. Borst, J. Yarrow
  • Medicine
  • American journal of physiology. Endocrinology and metabolism
  • 2015
Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone.
Bone health in hypogonadal men
  • M. Irwig
  • Medicine
  • Current opinion in urology
  • 2014
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DHEA in elderly women and DHEA or testosterone in elderly men.
Inhibition of 5alpha-reductase blocks prostate effects of testosterone without blocking anabolic effects.
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