Musculoskeletal and Neurologic Outcomes in Patients with Previously Treated Lyme Disease

@article{Shadick1999MusculoskeletalAN,
  title={Musculoskeletal and Neurologic Outcomes in Patients with Previously Treated Lyme Disease},
  author={Nancy A. Shadick and Charlotte B. Phillips and Oliver Sangha and Eric L Logigian and Richard Kaplan and Elizabeth Wright and Anne H. Fossel and K K Fossel and Victor Berardi and Robert Lew and Matthew Liang},
  journal={Annals of Internal Medicine},
  year={1999},
  volume={131},
  pages={919-926}
}
Lyme disease is a multisystem disorder of the skin, nervous system, heart, and joints (1-3) caused by tick-borne infection with Borrelia burgdorferi. Although the neurologic and musculoskeletal sequelae of Lyme disease are well described (4-10), their long-term clinical and functional effects in patients previously treated with antibiotics are not well understood. Several follow-up analyses demonstrated an increased prevalence of neurocognitive and musculoskeletal sequelae in persons with… 
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Post-treatment Lyme disease represents a narrow, defined, mechanistically-neutral subset of this larger, more heterogeneous group of patients, and is a useful definition in research settings as an initial subgroup of study.
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The overall current health status of each patient group was good, but sequelae were apparent primarily among patients with facial palsy who did not receive antibiotics for acute neuroborreliosis.
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Lyme disease (Lyme borreliosis).
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