Musculoskeletal and Neurologic Outcomes in Patients with Previously Treated Lyme Disease

  title={Musculoskeletal and Neurologic Outcomes in Patients with Previously Treated Lyme Disease},
  author={Nancy A. Shadick and Charlotte B. Phillips and Oliver Sangha and Eric L Logigian and Richard Kaplan and Elizabeth Wright and Anne H. Fossel and K K Fossel and Victor Berardi and Robert Lew and Matthew Liang},
  journal={Annals of Internal Medicine},
Lyme disease is a multisystem disorder of the skin, nervous system, heart, and joints (1-3) caused by tick-borne infection with Borrelia burgdorferi. Although the neurologic and musculoskeletal sequelae of Lyme disease are well described (4-10), their long-term clinical and functional effects in patients previously treated with antibiotics are not well understood. Several follow-up analyses demonstrated an increased prevalence of neurocognitive and musculoskeletal sequelae in persons with… 
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LA caused by active Bb infection, post-treatment LA with persistent knee synovitis and post-LD syndrome are distinct and distinguishable clinical entities.
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Post-treatment Lyme disease represents a narrow, defined, mechanistically-neutral subset of this larger, more heterogeneous group of patients, and is a useful definition in research settings as an initial subgroup of study.
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The prevalence of persistent symptoms in unselected patients with a history of Lyme disease was ascertained; their rheumatologic, neurologic, and health status outcomes were determined; and potential risk factors for these long-term sequelae were identified.
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Lyme disease may trigger fibromyalgia, but antibiotics do not seem to be effective in the treatment of the fibromyalgic symptoms, and only one patient is completely asymptomatic.
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This study sought to ascertain whether persons with a previous episode of treated Lyme disease have a higher prevalence of cardiac abnormalities than persons without previous Lyme disease.
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Within the last decade, Lyme borreliosis has emerged as a complex new infection whose distribution is worldwide. The disorder is caused by a recently recognized spirochete, B. burgdorferi,