Muscular response and adaptation to diabetes mellitus.

@article{Sun2008MuscularRA,
  title={Muscular response and adaptation to diabetes mellitus.},
  author={Zi-lin Sun and Li-li Liu and Naifeng Liu and Yuefei Liu},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2008},
  volume={13},
  pages={
          4765-94
        }
}
Diabetes mellitus (DM) is an epidemic medical challenge that threatens the health and life quality of people worldwide. DM impairs metabolic, neural and vascular function and thus has profound impacts on different systems and organs in the body. Though continuous endeavour has been made to study its etiology and mechanisms, no cure for DM has yet been found. DM development may be multi-factorial. The skeletal muscle is one of the most important systems, involved in the development of DM, and… Expand
Diabetes and Stem Cell Function
TLDR
Physical activity is proposed as a useful measure for the patients in diabetes to improve the physiological functions and to maintain their quality of life and the use of stem cell-based approaches in the context of diabetes treatment is discussed. Expand
Pathophysiology of muscle dysfunction in COPD.
TLDR
The present review examines the current state of the art of the pathophysiology of muscle dysfunction in COPD and finds that deconditioning seems to play a key role in peripheral muscle dysfunction. Expand
Muscle mitochondrial function in patients with type 2 diabetes mellitus and peripheral arterial disease: implications in vascular surgery.
TLDR
Muscle mitochondrial function is impaired in both T2DM and PAD patients, but differently and the NIRS technique appears to determine the degree of PAD better than (31)PMRS. Expand
Pulmonary Function and Sleep Breathing: Two New Targets for Type 2 Diabetes Care.
TLDR
The lung should be considered by those providing care for people with diabetes and raise the central issue of whether the normalization of glucose levels can improve pulmonary function and ameliorate sleep-disordered breathing. Expand
Reduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors.
TLDR
Because this distinctive feature of body composition becomes more evident as duration of diabetes is longer and less marked in patients with habitual exercise, early intervention, such as the instruction of exercise including resistance training, seems to be worthwhile for the prevention of future burdens in patients. Expand
Inspiratory muscle weakness is associated with autonomic cardiovascular dysfunction in patients with type 2 diabetes mellitus
TLDR
Patients with type 2 DM and autonomic neuropathy showed reduced respiratory muscle strength and less HR variability, suggesting that respiratory muscle weakness may be associated with autonomic dysfunction in these patients. Expand
Mitochondrial plasticity in pathophysiological conditions
TLDR
The results showed that in heart from aged mice there is an accumulation of dysfunctional mitochondria, and the impact of mitochondrial PQC system impairment in the accumulation of oxidized proteins, exacerbating the dysfunction of this organelle in striated muscle in several pathophysiological conditions. Expand
Differential features of muscle fiber atrophy in osteoporosis and osteoarthritis
TLDR
It is demonstrated that osteoporosis is associated with a preferential type II muscle fiber atrophy, which correlates with bone mineral density and reduced levels of Akt, a major regulator of muscle mass, which is connected to the functional impairment caused by the disease. Expand
The ups and downs of exercise and insulin sensitivity: a role for the myokine myostatin in glucose metabolism?
TLDR
The effects of acute and long-term exercise on myokine gene expression and insulin sensitivity in humans are analysed to help investigators direct future studies regarding the role of the growth factor myostatin on metabolism in muscle and adipose tissue. Expand
Prophylactic effects of swimming exercise on autophagy-induced muscle atrophy in diabetic rats
TLDR
It is proposed that autophagy inhibition induced by swimming exercise serves as a hypercatabolic mechanism in the skeletal muscles of diabetic rats, supporting a notion that swimming exercise could efficiently reverse the reduced skeletal muscle mass caused by diabetes. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 383 REFERENCES
Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus
  • E. Blaak
  • Medicine
  • The Proceedings of the Nutrition Society
  • 2004
TLDR
Disturbances in the capacity to increase fat oxidation during post-absorptive conditions, β-adrenergic stimulation and exercise in subjects who are obese and/or have type 2 diabetes persist after weight reduction, indicating that the diminished fat oxidation may be a primary factor leading to the obese and or insulin-resistant state rather than an adaptational response. Expand
The union of vascular and metabolic actions of insulin in sickness and in health.
TLDR
Treatment of vascular endothelial cells with the free fatty acid (FFA) palmitate activates IKKβ, impairs insulin signaling, and decreases insulin-stimulated production of nitric oxide, uncovering an additional link between metabolic and vascular pathophysiology that helps to explain mechanisms underlying the metabolic syndrome and related cardiovascular diseases. Expand
Mitochondria and Diabetes
TLDR
The authors speculate that the insulin resistance in patients with type 2 diabetes is caused by an inherited defect in mitochondrial oxidative phosphorylation, a condition often accompanied by the aberrant accumulation of intracellular fatty acids that are normally broken down by mitochondria. Expand
Insulin resistance in type 2 diabetes: role of fatty acids
  • P. Arner
  • Medicine
  • Diabetes/metabolism research and reviews
  • 2002
TLDR
A new class of antidiabetic agents, the thiazolidinediones (TZDs) or ‘glitazones’ has been developed and a prominent effect of these agents is the lowering of circulating FFA levels and it is believed, but not yet proven, that this interaction with FFAs constitutes a major mechanism behind the glucose‐lowering effect of the TZDs. Expand
Inflammatory pathways and insulin action
TLDR
The role of the JNK pathway in insulin receptor signaling, the impact of blocking this pathway in obesity and the mechanisms underlying JNK-induced insulin resistance will be discussed. Expand
Oxidative stress--mediated alterations in glucose dynamics in a genetic animal model of type II diabetes.
TLDR
The results suggest that skeletal muscle insulin resistance in GK rats appears to be of genetic origin and not merely related to a paracrine or autocrine effect, since this phenomenon is also observed in cultured myoblasts over several passages and heightened state of oxidative stress may mediate the development of insulin resistance during diabetes. Expand
Mechanisms of insulin resistance in humans and possible links with inflammation.
TLDR
Magnetic resonance spectroscopy studies in humans suggest that a defect in insulin-stimulated glucose transport in skeletal muscle is the primary metabolic abnormality in diabetes-resistant type 2 diabetics. Expand
Glucose metabolism in obesity and type 2 diabetes.
TLDR
The development of diabetes as a consequence of increasing insulin resistance in the obese diabetic subject is discussed, and the principal features--insulin resistance, elevated free fatty acid levels and glucotoxicity--are emphasized. Expand
Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia, and hyperinsulinemia.
TLDR
Because enhanced sympathetic activity has been associated with vascular hypertrophy and rarefaction of vascularization, overactivity in this part of the autonomic nervous system may lead to structural changes that will decrease the blood flow in peripheral tissues and induce the metabolic syndrome of cardiovascular risk factors, particularly in individuals who, for genetic reasons, have decreased capillarization at the onset. Expand
Oxidative stress impairs skeletal muscle repair in diabetic rats.
TLDR
Vitamin E administration to STZ-induced diabetic rats reverses oxidative imbalance and improves muscle gene transcription, reinforcing the suggestion that oxidative stress may play a role in diabetes-related impaired muscle repair. Expand
...
1
2
3
4
5
...