Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats.

@article{Taguchi2005MuscularMH,
  title={Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats.},
  author={Toru Taguchi and Teru Matsuda and Ryoko Tamura and Jun Sato and Kazue Mizumura},
  journal={The Journal of physiology},
  year={2005},
  volume={564 Pt 1},
  pages={259-68}
}
Delayed onset muscle soreness (DOMS) is quite common, but the mechanism for this phenomenon is still not understood; even the existence of muscle tenderness (mechanical hyperalgesia) has not been demonstrated in experimental models. We developed an animal model of DOMS by inducing eccentric contraction (lengthening contraction, ECC) to the extensor digitorum longus muscle (EDL), and investigated the existence of mechanical hyperalgesia in the EDL by means of behavioural pain tests (Randall… CONTINUE READING