Muscular adverse effects are common with statins

  title={Muscular adverse effects are common with statins},
  author={Peter Christian G{\o}tzsche},
  journal={BMJ : British Medical Journal},
  • P. Gøtzsche
  • Published 11 June 2014
  • Medicine
  • BMJ : British Medical Journal
The 2011 Cochrane review of statins for the primary prevention of cardiovascular disease reported a risk ratio of 1.03 for muscle pain—3% more patients developed muscle pain on the drug than on placebo.1 However, industry funded randomised trials are notoriously unreliable … 
3 Citations
Beyond confusion and controversy, can we evaluate the real efficacy and safety of cholesterol-lowering with statins?
It is found that once secondary analyses and subgroup analyses are excluded, statins do not appear to protect diabetics, and this strongly suggests that statins are not effective for cardiovascular prevention.
The effectiveness and cost-effectiveness of plant sterol or stanol-enriched functional foods as a primary prevention strategy for people with cardiovascular disease risk in England: a modeling study
It is found that daily consumption of enriched spread reduces CVD risks more for men and older age groups, and if consumers bear the full cost of enriched spreads, NHS savings arise from reduced CVD events.
Understanding adverse drug reactions in package leaflets – an exploratory survey among health care professionals
In the present surveys, health professionals had major difficulties understanding frequency information on side effects in package leaflets, and the great majority erroneously implied a causal relation between drug intake and the frequency of side effects, even though most side effects listed are symptoms commonly experienced in daily life.


Effects of statins on energy and fatigue with exertion: results from a randomized controlled trial.
No drug is without adverse effect potential, and fatigue and exertional intolerance are adverse effects reported by patients receiving statins.1,2 Little direct information is available regarding the
Adverse effects of statins
  • F. Godlee
  • Psychology
    BMJ : British Medical Journal
  • 2014
The BMJ and authors withdraw statements suggesting that adverse events occur in 18-20% of patients, and instead suggest that adverse event rates are more likely to be in the range of 0.1-0.5% in the general population.
Statins for the primary prevention of cardiovascular disease.
Reductions in all-cause mortality, major vascular events and revascularisations were found with no excess of adverse events among people without evidence of CVD treated with statins, and evidence available to date showed that primary prevention with statin is likely to be cost-effective and may improve patient quality of life.
Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare
Busting the industry myths, the business model of big pharma, Psychiatrists as drug pushers and more lies about happy pills are revealed.
Should people at low risk of cardiovascular disease take a statin?
Statins have no overall benefit for those at low risk of cardiovascular disease and 'prescribing guidelines should not be broadened', according to the World Health Organization.