Muscles, exercise and obesity: skeletal muscle as a secretory organ

@article{Pedersen2012MusclesEA,
  title={Muscles, exercise and obesity: skeletal muscle as a secretory organ},
  author={Bente Klarlund Pedersen and Mark A. Febbraio},
  journal={Nature Reviews Endocrinology},
  year={2012},
  volume={8},
  pages={457-465}
}
During the past decade, skeletal muscle has been identified as a secretory organ. Accordingly, we have suggested that cytokines and other peptides that are produced, expressed and released by muscle fibres and exert either autocrine, paracrine or endocrine effects should be classified as myokines. The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs… 

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