Muscles, exercise and obesity: skeletal muscle as a secretory organ

@article{Pedersen2012MusclesEA,
  title={Muscles, exercise and obesity: skeletal muscle as a secretory organ},
  author={B. Pedersen and M. Febbraio},
  journal={Nature Reviews Endocrinology},
  year={2012},
  volume={8},
  pages={457-465}
}
During the past decade, skeletal muscle has been identified as a secretory organ. Accordingly, we have suggested that cytokines and other peptides that are produced, expressed and released by muscle fibres and exert either autocrine, paracrine or endocrine effects should be classified as myokines. The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs… Expand
1,486 Citations

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to collect data to help researchers identify factors, such as certain proteins or genetic codes, that are secreted from muscle that are associated with the… Expand
ConditionsDisorder of Lipid Storage and Metabolism, Lipid Metabolism Disorders, Metabolic Disorder, (+1 more)
InterventionBehavioral
Interventional Clinical Trial
The study aim was to compare the effectiveness of combined training (CT; aerobic + resistance exercises) and high-intensity interval body weight training (HIITBW) on body composition… Expand
ConditionsBreast Cancer Female, Gynecologic Cancer, Menopause, (+1 more)
InterventionOther
Observational Clinical Trial
Childhood obesity is one of the most serious global public health challenges of the 21st century (Daniels et al., 2009). Mexico has the highest prevalence of obesity, (Secretaría de… Expand
ConditionsObesity, Overweight, Thinness
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