Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice.

@article{Lin2008MusclewideSO,
  title={Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice.},
  author={Shuo Lin and Marcin Maj and Gabriela Bezakova and Josef P. Magyar and Hans Rudolf Brenner and Markus A. Ruegg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 32},
  pages={11406-11}
}
Agrin and its receptor MuSK are required for the formation of the postsynaptic apparatus at the neuromuscular junction (NMJ). In the current model the local deposition of agrin by the nerve and the resulting local activation of MuSK are responsible for creating and maintaining the postsynaptic apparatus including clusters of acetylcholine receptors (AChRs). Concomitantly, the release of acetylcholine (ACh) and the resulting depolarization disperses those postsynaptic structures that are not… CONTINUE READING
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