Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18-24-month-old) dystrophic mdx mice.

@article{Mouisel2010MuscleWA,
  title={Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18-24-month-old) dystrophic mdx mice.},
  author={Etienne Mouisel and Alban Vignaud and Christophe Hourd{\'e} and Gillian Butler-Browne and Arnaud Ferry},
  journal={Muscle & nerve},
  year={2010},
  volume={41 6},
  pages={
          809-18
        }
}
The muscles of mdx mice progressively deteriorate with age. We wanted to know whether this is associated with a decrease in regenerative capacity and/or changes in the mammalian target of rapamycin complex (mTOR) signaling pathway. Muscles of mdx mice aged 5 weeks, 5, 12, and 18-24 months were studied. Maximal force and muscle weight of the older mice were decreased as compared to younger adult mice. Activation of the mTOR signaling pathway, i.e., phosphorylation of Akt (also known as protein… CONTINUE READING
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