Muscle wasting in disease: molecular mechanisms and promising therapies

@article{Cohen2014MuscleWI,
  title={Muscle wasting in disease: molecular mechanisms and promising therapies},
  author={Shenhav Cohen and James A Nathan and Alfred L Goldberg},
  journal={Nature Reviews Drug Discovery},
  year={2014},
  volume={14},
  pages={58-74}
}
Atrophy occurs in specific muscles with inactivity (for example, during plaster cast immobilization) or denervation (for example, in patients with spinal cord injuries). Muscle wasting occurs systemically in older people (a condition known as sarcopenia); as a physiological response to fasting or malnutrition; and in many diseases, including chronic obstructive pulmonary disorder, cancer-associated cachexia, diabetes, renal failure, cardiac failure, Cushing syndrome, sepsis, burns and trauma… CONTINUE READING
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