Muscle type-specific response of PGC-1 alpha and oxidative enzymes during voluntary wheel running in mouse skeletal muscle.

@article{Ikeda2006MuscleTR,
  title={Muscle type-specific response of PGC-1 alpha and oxidative enzymes during voluntary wheel running in mouse skeletal muscle.},
  author={Saori Ikeda and Hironobu Kawamoto and Kazuko Kasaoka and Yoshiaki Hitomi and Takako Kizaki and Yoshiyuki Sankai and Hideki Ohno and Shukoh Haga and Tohru Takemasa},
  journal={Acta physiologica},
  year={2006},
  volume={188 3-4},
  pages={217-23}
}
AIM It is generally accepted that endurance exercise increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), which governs the expression of oxidative metabolic enzymes. A previous report demonstrated that the regulation of mitochondrial protein expression in skeletal muscles in response to cold exposure depends on muscle fibre type. Cold exposure and endurance exercise are both metabolic challenges that require adjustments in mitochondrial… CONTINUE READING