Muscle synergies in children with dystonia capture “healthy” patterns regardless the altered motor performance

  title={Muscle synergies in children with dystonia capture “healthy” patterns regardless the altered motor performance},
  author={Francesca Lunardini and C. Casellato and M. Bertucco and T. Sanger and A. Pedrocchi},
  journal={2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)},
Muscle synergies are hypothesized to represent motor modules recruited by the nervous system to flexibly perform subtasks necessary to achieve movement. Muscle synergy analysis may offer a better view of the neural structure underlying motor behaviors and how they change in motor deficits and rehabilitation. The aim of this study is to investigate if muscle synergies are able to encode regularities in the musculoskeletal system organization and dynamic behavior of patients with dystonia, or if… Expand
Children With and Without Dystonia Share Common Muscle Synergies While Performing Writing Tasks
Results suggest that the synergy analysis has the ability of capturing the uncorrupted part of the electromyographic signal in dystonia, and supports a possible future use of muscle synergies in the design of myocontrol interfaces for children with dySTONia. Expand
Sensorimotor Control in Dystonia
This overview of relevant research regarding sensorimotor control in humans with idiopathic dystonia attempts to frame the dysfunction with respect to what is known regarding motor control in patients and healthy individuals. Expand
High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation
It is confirmed that motor variability on a trial-by-trial basis was selectively increased in the homogenous and prototypical dystonic disorder DYT1 dystonia and suggested that high baseline variability predicted poor performance in the subsequent visuomotor adaptation task offering insight into the rules which appear to govern dySTONic motor control. Expand
Can spatial filtering separate voluntary and involuntary components in children with dyskinetic cerebral palsy?
It is found that abnormal movement in dyskinetic CP is consistent with a pervasive distortion of voluntary movement rather than a superposition of separable voluntary and involuntary components of movement. Expand
What can kinematic studies tell us about the mechanisms of dystonia?
The results build on previous studies, confirming that motor variability on a trial-by-trial basis is selectively increased and provide evidence that increases in variability are negatively related to forms of motor learning essential for healthy motor control. Expand
Synergy-Based Myocontrol of a Two Degree of Freedom Robotic Arm in Children with Dystonia
The proposed synergy-based scheme showed a better performance compared to the traditional muscle-pair approach, both in dynamic and isometric conditions. Expand
Defining movement instabilities in yips golfers using motion capture and muscle synergies.
Despite a strong subjective feeling of yips that golfers complain of, movement analysis can reliably exclude those with 'choking' from those with task-specific dystonias, and movement instabilities are consistently identified as abnormal muscle synergy patterns. Expand
The role of the cerebellum in the pathophysiology of dystonia
Overall, the application of the ‘purest’ cerebellar paradigms did not provide a robust functional correlate to implicate specific cerebellum functions as a driver of dystonic pathophysiology, and isolated dystonia does not seem to selectively impair cerebellary functions. Expand
Why orthotic devices could be of help in the management of Movement Disorders in the young
Design principles will be derived to provide specialised orthoses for the dynamic control of posture and the stabilisation of voluntary movements: those include using biomechanical actions and enhanced proprioception to support the sensorimotor rehabilitation of the children affected by CD. Expand
A Smart Ink Pen for the Ecological Assessment of Age-Related Changes in Writing and Tremor Features
The smartpen is particularly suitable for daily-life telemonitoring applications in a number of important health-related fields and has the ability to combine the advantages of the digitizing tablet technology with the natural “feel,” the ease of use, and the ecological validity of the traditional pen-and-paper approach. Expand


Increased task-uncorrelated muscle activity in childhood dystonia
An innovative and practical method to objectively measure movement abnormalities during the performance of a continuous figure-eight writing task in children with dystonia and 9 age-matched healthy controls is presented, consistent with the hypothesis that the ability to appropriately suppress variable and uncorrelated elements of movement is impaired. Expand
Merging of healthy motor modules predicts reduced locomotor performance and muscle coordination complexity post-stroke.
A common modular organization of muscle coordination underlying walking in both healthy and post-stroke subjects is suggested, which may lead to new insight into impaired locomotor coordination and the underlying neural systems. Expand
Muscle synergy patterns as physiological markers of motor cortical damage
Three distinct patterns of muscle coordination that reflect the multiple neural responses that occur after cortical damage are revealed and can be used as physiological markers of the status of any patient with stroke or trauma, thereby guiding the development of different rehabilitation approaches. Expand
Central and Sensory Contributions to the Activation and Organization of Muscle Synergies during Natural Motor Behaviors
It is speculated that sensory feedback might adapt recruitment of muscle synergies to behavioral constraints, and the few synergies specific to the intact or deafferented states might represent afferent-specific modules or feedback reorganization of spinal neuronal networks. Expand
Modulation of phasic and tonic muscle synergies with reaching direction and speed.
It is found that the amplitude modulation of three time-invariant synergies captured the variations in the postural muscle patterns at the end of the movement, suggesting that muscle synergies are basic control modules that allow generating the appropriate muscle patterns through simple modulation and combination rules. Expand
Distributed neural networks for controlling human locomotion Lessons from normal and SCI subjects
Kinematics training may provide a more successful rehabilitation than training based on reconstructing normal muscle activation patterns, and recent data support the idea of plasticity and distributed networks for controlling human locomotion. Expand
Reaching and Writing Movements: Sensitive and Reliable Tools to Measure Genetic Dystonia in Children
The results support the hypothesis that basal ganglia dysfunction is responsible for compromising the motor activity focusing and contribute toward a reliable assessment of pure dystonia. Expand
Reaching Movements in Childhood Dystonia Contain Signal-Dependent Noise
It is predicted that slower movement in children with dystonia is at least partly due to a compensatory strategy to reduce variability by decreasing speed, and a simple computational model is presented that provides a possible explanation for the origin of this noise. Expand
Relationships between timing of muscle excitation and impaired motor performance during cyclical lower extremity movement in post-stroke hemiplegia.
The results suggest that muscles were differently affected depending on their function, external power-producing muscles (e.g. vastus medialis and semimembranosus) showing prolonged excitation and muscles that normally maintain crank progression during limb transitions showing phase-advanced excitation. Expand
The physiology of idiopathic dystonia.
  • C. Marsden, J. Rothwell
  • Medicine
  • The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
  • 1987
Dystonia is mysterious and its pathophysiology is uncertain. The fundamental motor abnormality is an abnormality of muscle command signals, such that the wrong agonists may be activated for too long,Expand