Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.

Abstract

Insulin resistance is one of the primary characteristics of type 2 diabetes. Mice overexpressing a dominant-negative IGF-I receptor specifically in muscle (MKR mice) demonstrate severe insulin resistance with high levels of serum and tissue lipids and eventually develop type 2 diabetes at 5-6 wk of age. To determine whether lipotoxicity plays a role in the… (More)

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@article{HronMilhavet2004MusclespecificOO, title={Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.}, author={Lisa H{\'e}ron-Milhavet and Martin Haluz{\'i}k and Shoshana Yakar and Oksana Gavrilova and Stephanie Pack and William Jou and Azeddine Ibrahimi and Hyunsook Kim and Desmond G. Hunt and Daphne Yau and Zeenat A. Asghar and Jamie Joseph and Michael B. Wheeler and Nada A. Abumrad and Derek Leroith}, journal={Endocrinology}, year={2004}, volume={145 10}, pages={4667-76} }