Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice.

@article{Klooster2012MusclespecificKM,
  title={Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice.},
  author={Rinse Klooster and Jaap J. Plomp and Maartje G M Huijbers and Erik H. Niks and Kirsten R. Straasheijm and Frank J M Detmers and Pim W Hermans and Kevin Sleijpen and Aad Verrips and Mario Losen and Pilar Mart{\'i}nez-Mart{\'i}nez and Marc H. de Baets and Silv{\'e}re M. van der Maarel and Jan J G M Verschuuren},
  journal={Brain : a journal of neurology},
  year={2012},
  volume={135 Pt 4},
  pages={1081-101}
}
Myasthenia gravis is a paralytic disorder with autoantibodies against acetylcholine receptors at the neuromuscular junction. A proportion of patients instead has antibodies against muscle-specific kinase, a protein essential for acetylcholine receptor clustering. These are generally of the immunoglobulin-G4 subclass and correlate with disease severity, suggesting specific myasthenogenic activity. However, immunoglobulin-G4 subclass antibodies are generally considered to be 'benign' and direct… CONTINUE READING

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MuSK IgG 4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp 4

Maartje G. Huijbersa, Wei Zhangc, +11 authors Jan J. Verschuurena
2013
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