Muscle-specific expression of hepatitis B surface antigen: no effect on DNA-raised immune responses.

@article{Loirat1999MusclespecificEO,
  title={Muscle-specific expression of hepatitis B surface antigen: no effect on DNA-raised immune responses.},
  author={Delphine Loirat and Zhan-fei Li and Maryline Mancini and P. Tiollais and Denise Paulin and M. L. Michel},
  journal={Virology},
  year={1999},
  volume={260 1},
  pages={74-83}
}
The injection of plasmid DNA encoding hepatitis B virus (HBV) envelope proteins in mouse muscle leads to the induction of specific humoral and cellular immune responses. Most studies on DNA-based immunization have used viral promoters to drive antigen expression. In this study, we compared the efficiency of a muscle-specific promoter, the human desmin gene promoter, with the commonly used cytomegalovirus (CMV) early gene promoter. We showed that increased in vitro expression of HBV envelope… CONTINUE READING

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