Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress.

@article{Wheeler1995MusclespecificEO,
  title={Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress.},
  author={Joseph C. Wheeler and Erik T Bieschke and J. E. Tower},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 22},
  pages={10408-12}
}
Induction of Drosophila hsp70 protein was detected during aging in flight muscle and leg muscle in the absence of heat shock, using an hsp70-specific monoclonal antibody, and in transgenic flies containing hsp70-beta-galactosidase fusion protein reporter constructs. While hsp70 and reporter proteins were induced during aging, hsp70 message levels were not, indicating that aging-specific induction is primarily posttranscriptional. In contrast, hsp22 and hsp23 were found to be induced during… CONTINUE READING

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