Muscle-specific and inducible expression of 293-base pair beta-myosin heavy chain promoter in transgenic mice.

@article{Wiedenman1996MusclespecificAI,
  title={Muscle-specific and inducible expression of 293-base pair beta-myosin heavy chain promoter in transgenic mice.},
  author={J L Wiedenman and Gretchen L. Tsika and Luoyi Gao and Jeanette J. McCarthy and Ilia Rivera-Rivera and Dhiraj Vyas and K D Sheriff-Carter and Richard W Tsika},
  journal={The American journal of physiology},
  year={1996},
  volume={271 3 Pt 2},
  pages={R688-95}
}
The DNA regulatory element(s) involved in beta-myosin heavy chain (beta-MHC) induction by the physiological stimulus of mechanical overload have not been identified as yet. To delineate regulatory sequences that are required for mechanical overload induction of the beta-MHC gene, transgenic mouse lines were generated that harbor transgenes containing serial deletions of the human beta-MHC promoter to nucleotides -293 (beta 293), -201 (beta 201), and -141 (beta 141) from the transcription start… CONTINUE READING
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