Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development.

@article{McElhinny2004MusclespecificRF,
  title={Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development.},
  author={Abigail S. McElhinny and Cynthia N. Perry and Christian C. Witt and Siegfried Labeit and Carol C. Gregorio},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 15},
  pages={
          3175-88
        }
}
The efficient functioning of striated muscle is dependent upon the structure of several cytoskeletal networks including myofibrils, microtubules, and intermediate filaments. However, little is known about how these networks function together during muscle differentiation and maintenance. In vitro studies suggest that members of the muscle-specific RING finger protein family (MURF-1, 2, and 3) act as cytoskeletal adaptors and signaling molecules by associating with myofibril components… CONTINUE READING
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