Muscle satellite cells adopt divergent fates a mechanism for self-renewal?

@inproceedings{Zammit2004MuscleSC,
  title={Muscle satellite cells adopt divergent fates a mechanism for self-renewal?},
  author={Peter S Zammit and Jon P Golding and Yosuke Nagata and Valérie Hudon and Terence A. Partridge and Jonathan R. Beauchamp},
  year={2004}
}
rowth, repair, and regeneration of adult skeletal muscle depends on the persistence of satellite cells: muscle stem cells resident beneath the basal lamina that surrounds each myofiber. However, how the satellite cell compartment is maintained is unclear. Here, we use cultured myofibers to model muscle regeneration and show that satellite cells adopt divergent fates. Quiescent satellite cells are synchronously activated to coexpress the transcription factors Pax7 and MyoD. Most then proliferate… CONTINUE READING

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