Muscle ring finger 1 mediates cardiac atrophy in vivo.

  title={Muscle ring finger 1 mediates cardiac atrophy in vivo.},
  author={Monte S Willis and Mauricio Rojas and Luge Li and Craig H. Selzman and Ru-hang Tang and William Elliott Stansfield and Jessica L. Rodriguez and David J Glass and C. G. Patterson},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={296 4},
Pathological cardiac hypertrophy, induced by various etiologies such as high blood pressure and aortic stenosis, develops in response to increased afterload and represents a common intermediary in the development of heart failure. Understandably then, the reversal of pathological cardiac hypertrophy is associated with a significant reduction in cardiovascular event risk and represents an important, yet underdeveloped, target of therapeutic research. Recently, we determined that muscle ring… CONTINUE READING


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