Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders.

@article{Debrosse2016MuscleOP,
  title={Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders.},
  author={Catherine Debrosse and Ravi Prakash Nanga and Neil E. Wilson and Kevin D'Aquilla and Mark A. Elliott and Hari Hariharan and Felicia Yan and Kristin Wade and Sara Nguyen and Diana Worsley and Chevonne Parris-Skeete and Elizabeth M. McCormick and Rui Xiao and Zuela Zolkipli Cunningham and Lauren Fishbein and Katherine L Nathanson and David R Lynch and Virginia A. Stallings and Marc Yudkoff and Marni J. Falk and Ravinder Reddy and Shana E McCormack},
  journal={JCI insight},
  year={2016},
  volume={1 18},
  pages={
          e88207
        }
}
Systemic mitochondrial energy deficiency is implicated in the pathophysiology of many age-related human diseases. Currently available tools to estimate mitochondrial oxidative phosphorylation (OXPHOS) capacity in skeletal muscle in vivo lack high anatomic resolution. Muscle groups vary with respect to their contractile and metabolic properties. Therefore, muscle group-specific estimates of OXPHOS would be advantageous. To address this need, a noninvasive creatine chemical exchange saturation… CONTINUE READING
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