Muscle metaboreflex-induced increases in cardiac sympathetic activity vasoconstrict the coronary vasculature.

@article{OLeary2007MuscleMI,
  title={Muscle metaboreflex-induced increases in cardiac sympathetic activity vasoconstrict the coronary vasculature.},
  author={Donal S. O'Leary and Javier A. Sala-Mercado and Robert L. Hammond and Eric J Ansorge and Jong-Kyung Kim and Jaime Correa Rodriguez and Dominic Fano and Masashi J Ichinose},
  journal={Journal of applied physiology},
  year={2007},
  volume={103 1},
  pages={190-4}
}
Ischemia of active skeletal muscle evokes a powerful blood pressure-raising reflex termed the muscle metaboreflex (MMR). MMR activation increases cardiac sympathetic nerve activity, which increases heart rate, ventricular contractility, and cardiac output (CO). However, despite the marked increase in ventricular work, no coronary vasodilation occurs. Using conscious, chronically instrumented dogs, we observed MMR-induced changes in arterial pressure, CO, left circumflex coronary blood flow (CBF… CONTINUE READING