Muscle metaboreflex control of ventricular contractility during dynamic exercise.

@article{SalaMercado2006MuscleMC,
  title={Muscle metaboreflex control of ventricular contractility during dynamic exercise.},
  author={Javier A. Sala-Mercado and Robert L. Hammond and Jong-Kyung Kim and Noreen F Rossi and Larry W. Stephenson and Donal S. O'Leary},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 2},
  pages={H751-7}
}
When oxygen delivery to active skeletal muscle is insufficient for the metabolic demands, afferent nerves within muscles are activated, which elicit reflex increases in heart rate (HR), cardiac output (CO), and arterial pressure (AP), termed the muscle metaboreflex (MMR). To what extent the increases in CO are the result of increased ventricular contractility is unclear. A widely accepted index of contractility is maximal left ventricular elastance (Emax), the slope of the end-systolic pressure… CONTINUE READING

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