Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear.

@article{Osman2008MusclelikeNR,
  title={Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear.},
  author={Abdullah A. Osman and Angela D Schrader and Aubrey J Hawkes and Omar Akil and Adam L. Bergeron and Lawrence R Lustig and Dwayne D Simmons},
  journal={Molecular and cellular neurosciences},
  year={2008},
  volume={38 2},
  pages={153-69}
}
Nothing is known about the regulation of nicotinic acetylcholine receptors (nAChRs) in hair cells of the inner ear. MuSK, rapsyn and RIC-3 are accessory molecules associated with muscle and brain nAChR function. We demonstrate that these accessory molecules are expressed in the inner ear raising the possibility of a muscle-like mechanism for clustering and assembly of nAChRs in hair cells. We focused our investigations on rapsyn and RIC-3. Rapsyn interacts with the cytoplasmic loop of nAChR… CONTINUE READING

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