Muscle interstitial ATP and norepinephrine concentrations in the human leg during exercise and ATP infusion.

@article{Mortensen2009MuscleIA,
  title={Muscle interstitial ATP and norepinephrine concentrations in the human leg during exercise and ATP infusion.},
  author={Stefan P Mortensen and Jos{\'e} Gonz{\'a}lez-Alonso and J Nielsen and Bengt Saltin and Ylva Hellsten},
  journal={Journal of applied physiology},
  year={2009},
  volume={107 6},
  pages={1757-62}
}
ATP has been proposed to play multiple roles in local skeletal muscle blood flow regulation by inducing vasodilation and modulating sympathetic vasoconstrictor activity, but the mechanisms remain unclear. Here we evaluated the effects of arterial ATP infusion and exercise on leg muscle interstitial ATP and norepinephrine (NE) concentrations to gain insight into the interstitial and intravascular mechanisms by which ATP causes muscle vasodilation and sympatholysis. Leg hemodynamics and muscle… CONTINUE READING

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