Muscle insensitivity to tetrodotoxin: induction by alpha-bungarotoxin and removal by submechanical threshold stimulation.

@article{Gruener1976MuscleIT,
  title={Muscle insensitivity to tetrodotoxin: induction by alpha-bungarotoxin and removal by submechanical threshold stimulation.},
  author={Raphael Gruener and N Baumbach},
  journal={Journal of neurobiology},
  year={1976},
  volume={7 6},
  pages={513-9}
}
Intramuscular injection of alpha-bungarotoxin (alphaBGT) into rat extensor digitorum longus muscles produced pharmacological blockade of neuromuscular transmission and resulted in denervation-like changes (Berg, D. and Hall, Z. (1975), J. Physiol. (London) 244:659-676). More than 80% of fibers from alphaBGT-injected muscles produced action potentials (ap's) in the presence of tetrodotoxin (TTX, 1 X 10(-6) M). Chronic electrical stimulation of these muscles, below the level necessary to elicit a… CONTINUE READING