Muscle insensitivity to tetrodotoxin: induction by alpha-bungarotoxin and removal by submechanical threshold stimulation.


Intramuscular injection of alpha-bungarotoxin (alphaBGT) into rat extensor digitorum longus muscles produced pharmacological blockade of neuromuscular transmission and resulted in denervation-like changes (Berg, D. and Hall, Z. (1975), J. Physiol. (London) 244:659-676). More than 80% of fibers from alphaBGT-injected muscles produced action potentials (ap's… (More)


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