Muscle inflammation and MHC class I up-regulation in muscular dystrophy with lack of dysferlin: an immunopathological study.

@article{Confalonieri2003MuscleIA,
  title={Muscle inflammation and MHC class I up-regulation in muscular dystrophy with lack of dysferlin: an immunopathological study.},
  author={Paolo Confalonieri and Laura Oliva and Francesca Andreetta and Rossella Lorenzoni and Patrizia Dassi and Elisabetta Mariani and Lucia Morandi and Marina Mora and Ferdinando Cornelio and Renato Mantegazza},
  journal={Journal of neuroimmunology},
  year={2003},
  volume={142 1-2},
  pages={130-6}
}
Muscle inflammation is characteristic of inflammatory myopathies but also occurs in muscular dystrophy with lack of the sarcolemmal protein dysferlin. We quantified inflammatory cells and major histocompatibility complex (MHC) expression in muscle from 10 patients with dysferlinopathy. Infiltrating cells were always present although numbers varied considerably; macrophages were more common than T cells, T cytotoxicity was absent, and MHC class I was overexpressed on muscle fibers. These… CONTINUE READING

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