Muscle hypertrophy is associated with increases in proteasome activity that is independent of MuRF1 and MAFbx expression

@inproceedings{Baehr2014MuscleHI,
  title={Muscle hypertrophy is associated with increases in proteasome activity that is independent of MuRF1 and MAFbx expression},
  author={Leslie M. Baehr and Matthew Tunzi and Sue C. Bodine},
  booktitle={Front. Physiol.},
  year={2014}
}
The regulation of skeletal muscle mass depends on the balance between protein synthesis and degradation. The role of protein degradation and in particular, the ubiquitin proteasome system, and increased expression of the E3 ubiquitin ligases, MuRF1 and MAFbx/atrogin-1, in the regulation of muscle size in response to growth stimuli is unclear. Thus, the aim of this study was to measure both proteasome activity and protein synthesis in mice over a 14-day period of chronic loading using the… CONTINUE READING
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Citation: Baehr LM, Tunzi M and Bodine SC (2014) Muscle hypertrophy is associated with increases in proteasome activity that is independent of MuRF1 and MAFbx expression

  • February
  • Front. Physiol. 5:69. doi: 10.3389/fphys.2014…
  • 2014
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