Muscle hypercatabolism during cancer cachexia is not reversed by the glucocorticoid receptor antagonist RU38486.

@article{Llovera1996MuscleHD,
  title={Muscle hypercatabolism during cancer cachexia is not reversed by the glucocorticoid receptor antagonist RU38486.},
  author={Marta Llovera and C{\`e}lia Garc{\'i}a-Mart{\'i}nez and Paola Costelli and Neus Agell and Neus Carb{\'o} and Francisco Javier L{\'o}pez-Soriano and Josep Maria Argil{\'e}s},
  journal={Cancer letters},
  year={1996},
  volume={99 1},
  pages={7-14}
}
In rats into which a fast growing ascites hepatoma (Yoshida AH-130) had been transplanted, tumor growth elicited a marked loss of body weight and tissue waste, particularly of the skeletal muscle. This depletion has been associated with enhanced rates of protein breakdown, mainly due to hyperactivation of the ATP-ubiquitin-dependent proteolytic system [Llovera, M., García-Martínez, C., Agell, N., Marzábal, M., López-Soriano, F.J. and Argilés, J.M. (1994) FEBS Lett., 338, 311-318]. Profound… CONTINUE READING

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