Muscle giants: molecular scaffolds in sarcomerogenesis.

@article{KontrogianniKonstantopoulos2009MuscleGM,
  title={Muscle giants: molecular scaffolds in sarcomerogenesis.},
  author={Aikaterini Kontrogianni-Konstantopoulos and Maegen A. Ackermann and Amber L Bowman and Solomon V. Yap and Robert J Bloch},
  journal={Physiological reviews},
  year={2009},
  volume={89 4},
  pages={
          1217-67
        }
}
Myofibrillogenesis in striated muscles is a highly complex process that depends on the coordinated assembly and integration of a large number of contractile, cytoskeletal, and signaling proteins into regular arrays, the sarcomeres. It is also associated with the stereotypical assembly of the sarcoplasmic reticulum and the transverse tubules around each sarcomere. Three giant, muscle-specific proteins, titin (3-4 MDa), nebulin (600-800 kDa), and obscurin (approximately 720-900 kDa), have been… CONTINUE READING
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