Muscle giants: molecular scaffolds in sarcomerogenesis.

  title={Muscle giants: molecular scaffolds in sarcomerogenesis.},
  author={Aikaterini Kontrogianni-Konstantopoulos and Maegen A. Ackermann and Amber L Bowman and Solomon V. Yap and Robert J Bloch},
  journal={Physiological reviews},
  volume={89 4},
Myofibrillogenesis in striated muscles is a highly complex process that depends on the coordinated assembly and integration of a large number of contractile, cytoskeletal, and signaling proteins into regular arrays, the sarcomeres. It is also associated with the stereotypical assembly of the sarcoplasmic reticulum and the transverse tubules around each sarcomere. Three giant, muscle-specific proteins, titin (3-4 MDa), nebulin (600-800 kDa), and obscurin (approximately 720-900 kDa), have been… CONTINUE READING
Highly Cited
This paper has 142 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 86 extracted citations

A rising titan: TTN review and mutation update.

View 6 Excerpts
Highly Influenced

The sarcomeric cytoskeleton: from molecules to motion.

The Journal of experimental biology • 2016
View 2 Excerpts
Highly Influenced

Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo.

Developmental dynamics : an official publication of the American Association of Anatomists • 2014
View 3 Excerpts
Highly Influenced

143 Citations

Citations per Year
Semantic Scholar estimates that this publication has 143 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 427 references

The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin TITIN, NEBULIN, AND OBSCURIN: MYOFIBRILLAR SCAFFOLDS

AL Bowman, DH Catino, +3 authors RJ. Bloch
Physiol Rev • VOL • 2009
View 6 Excerpts
Highly Influenced

Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy

Journal of Muscle Research & Cell Motility • 2005
View 9 Excerpts
Highly Influenced