Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G.

@article{Wiendl2000MuscleFI,
  title={Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G.},
  author={Heinz Wiendl and L{\"u}der Behrens and Sabine Maier and Marcia A. Johnson and Elisabeth H. Weiss and Reinhard Hohlfeld},
  journal={Annals of neurology},
  year={2000},
  volume={48 4},
  pages={679-84}
}
We demonstrate that HLA-G, a nonclassical major histocompatibility complex class I antigen, is expressed in muscle fibers in various inflammatory myopathies. Further, interferon-gamma induces surface expression and upregulation of mRNA transcripts corresponding to different isoforms of HLA-G in myoblasts cultured from control subjects and patients. HLA-G may have important immunological functions in inflammatory myopathies and other local immune reactions as they occur during vaccination… CONTINUE READING

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