Muscle fiber necrosis associated with human marathon runners.

  title={Muscle fiber necrosis associated with human marathon runners.},
  author={Robert S. Hikida and Robert S. Staron and Fredrick C. Hagerman and William Michael Sherman and David L. Costill},
  journal={Journal of the neurological sciences},
  volume={59 2},
This study describes the events occurring in exercise-induced muscular necrosis. Biopsies of the gastrocnemius muscles of volunteer human marathon runners were extracted prior to and at intervals for 7 days following a marathon, and investigated ultrastructurally. Most of the preparations, including the pre-marathon samples, showed evidence of muscle fiber necrosis and inflammation. These preparations had many mitochondria, erythrocytes, leukocytes and other phagocytic cells within the… CONTINUE READING


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