Muscle excitability abnormalities in Machado-Joseph disease.

@article{Frana2008MuscleEA,
  title={Muscle excitability abnormalities in Machado-Joseph disease.},
  author={Marcondes C França and Anelyssa D'abreu and Anamarli Nucci and Iscia T Lopes-Cendes},
  journal={Archives of neurology},
  year={2008},
  volume={65 4},
  pages={525-9}
}
OBJECTIVES To estimate the frequency of and to characterize muscle excitability abnormalities in Machado-Joseph disease (MJD). DESIGN Machado-Joseph disease is a common autosomal dominant cerebellar ataxia caused by an unstable CAG trinucleotide repeat expansion. Muscle cramps and fasciculations are frequent and sometimes disabling manifestations. However, their frequency and pathophysiological mechanisms remain largely unknown. Symptomatic patients with MJD (hereinafter MJD patients) with… CONTINUE READING