Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons.

Abstract

The production of neurotrophin-4 (NT-4) in rat skeletal muscle was found to depend on muscle activity. The amounts of NT-4 messenger RNA present decreased after blockade of neuromuscular transmission with alpha-bungarotoxin and increased during postnatal development and after electrical stimulation in a dose-dependent manner. NT-4 immunoreactivity was… (More)

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@article{Funakoshi1995MusclederivedNA, title={Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons.}, author={Hidefumi Funakoshi and Natale Belluardo and Ernest Arenas and Yuki Yamamoto and Antonino Casabona and H{\aa}kan Persson and Carlos F. Ib{\'a}{\~n}ez}, journal={Science}, year={1995}, volume={268 5216}, pages={1495-9} }