Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle.

@article{Pedersen2012MusclederivedEO,
  title={Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle.},
  author={Line Kynemund Pedersen and Caroline Holkmann Olsen and Bente Klarlund Pedersen and Pernille Hojman},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={302 7},
  pages={E831-40}
}
Serum levels and muscle expression of the chemokine CXCL1 increase markedly in response to exercise in mice. Because several studies have established muscle-derived factors as important contributors of metabolic effects of exercise, this study aimed at investigating the effect of increased expression of muscle-derived CXCL1 on systemic and intramuscular metabolic parameters, with focus on fatty acid oxidation and oxidative metabolism in skeletal muscle. By overexpression of CXCL1 in the… CONTINUE READING
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