Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction

@article{Huard2002MusclederivedCE,
  title={Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction},
  author={Johnny Huard and Teruhiko Yokoyama and Ryan Pruchnic and Zhuqing Qu and Y Li and J Y Lee and George T. Somogyi and William C. de Groat and Michel B Chancellor},
  journal={Gene Therapy},
  year={2002},
  volume={9},
  pages={1617-1626}
}
We have tested the feasibility of muscle-based gene therapy and tissue engineering for urological dysfunction using highly purified muscle-derived cells (MDC) that display stem cell characteristics. We then explored the potential use of these MDC as an alternative therapy for the treatment of impaired detrusor contractility. The MDC were genetically engineered to express the gene encoding β-galactosidase and injected into the bladder walls of SCID mice. The injected bladders were harvested at… CONTINUE READING
35 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration

  • Z Qu-Petersen
  • J Cell Biol
  • 2002

Similar Papers

Loading similar papers…