Muscle-derived ROS and thiol regulation in muscle fatigue.

  title={Muscle-derived ROS and thiol regulation in muscle fatigue.},
  author={Leonardo F. Ferreira and Michael B. Reid},
  journal={Journal of applied physiology},
  volume={104 3},
Muscles produce oxidants, including reactive oxygen species (ROS) and reactive nitrogen species (RNS), from a variety of intracellular sources. Oxidants are detectable in muscle at low levels during rest and at higher levels during contractions. RNS depress force production but do not appear to cause fatigue of healthy muscle. In contrast, muscle-derived ROS contribute to fatigue because loss of function can be delayed by ROS-specific antioxidants. Thiol regulation appears to be important in… 

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