Muscle denervation increases the levels of two mRNAs coding for the acetylcholine receptor alpha-subunit.

@article{Goldman1985MuscleDI,
  title={Muscle denervation increases the levels of two mRNAs coding for the acetylcholine receptor alpha-subunit.},
  author={Daniel Goldman and Jim Boulter and Stephen J Heinemann and Jim Patrick},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1985},
  volume={5 9},
  pages={2553-8}
}
The mRNA coding for the alpha-subunit of the acetylcholine receptor was studied in mouse leg and rat diaphragm muscle. We find that denervation of rat diaphragm results in a 7-fold increase in mRNA coding for the alpha-subunit, whereas denervation of mouse leg muscle results in approximately a 50-fold increase in alpha-subunit-specific mRNA. The relationship of the mRNAs purified from innervated and denervated muscle was investigated by SI nuclease mapping. Two mRNA species were found in both… CONTINUE READING

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