Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles.

@article{Hokari2010MuscleCA,
  title={Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles.},
  author={Fumi Hokari and Emi Kawasaki and Atsushi Sakai and Keiichi Koshinaka and Kunihiro Sakuma and Kentaro Kawanaka},
  journal={Journal of applied physiology},
  year={2010},
  volume={109 2},
  pages={332-40}
}
Sirt3, a member of the sirtuin family, is known to control cellular mitochondrial function. Furthermore, because sirtuins require NAD for their deacetylase activity, nicotinamide phosphoribosyltransferase (Nampt), which is a rate-limiting enzyme in the intracellular NAD biosynthetic pathway, influences their activity. We examined the effects of exercise training and normal postural contractile activity on Sirt3 and Nampt protein expression in rat skeletal muscles. Male rats were trained by… CONTINUE READING
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Effects of Exercise and Immobilization on Sirt3 in Skeletal Muscles

  • JA Baur, KJ Pearson, +20 authors P Navas
  • J Appl Physiol
  • 2010
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