Muscle cells produce a low molecular weight factor with anti-cancer activity

@article{Djaldetti1996MuscleCP,
  title={Muscle cells produce a low molecular weight factor with anti-cancer activity},
  author={Meir Djaldetti and Benjamin Sredni and R. Zigelman and Moshe Verber and Pnina Fishman},
  journal={Clinical & Experimental Metastasis},
  year={1996},
  volume={14},
  pages={189-196}
}
The present study describes a new low molecular weight factor released by muscle cells, which inhibits proliferation of tumor cells in vitro and in vivo, is highly specific towards tumor cells, and has no observable effect on normal cells' proliferation. What first prompted us to investigate this factor was the observation that tumor metastases are extremely rare in striated muscles. Co-culturing of striated muscle cells with malignant cells led to marked morphological alterations in the latter… CONTINUE READING

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