Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway.

Abstract

Muscle wasting (cachexia) is an incurable complication associated with chronic infection and cancers that leads to an overall poor prognosis for recovery. Tumor necrosis factor-alpha (TNFalpha) is a key inflammatory cytokine associated with cachexia. TNFalpha inhibits myogenic differentiation and skeletal muscle regeneration through downstream effectors of… (More)

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Cite this paper

@article{Schwarzkopf2006MuscleCI, title={Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway.}, author={Martina Schwarzkopf and Dario Coletti and David A. Sassoon and Giovanna Marazzi}, journal={Genes & development}, year={2006}, volume={20 24}, pages={3440-52} }